THE FIRST COHOMOLOGY GROUP OF AN ALGEBRA WITH COEFFICIENTS Claude CIBILS Manuel SAORIN In this paper we provide formulas for the dimension of the first Hochschild cohomology vector space of an algebra with a separable splitting subalgebra and coefficients in a bimodule. We first consider a monomial non-commutative algebra, in order to provide a simpler specific formula in this case and to sketch the methods used in the sequel. Recall that such an algebra is the quotient of the path algebra of a quiver by a two-sided ideal generated by oriented paths of length at least 2. The important point is that the quiver can afford oriented cycles. The computation is based on a modelization of cohomological tools and on a computation of the center of those algebras. In Section 3, we tackle the most general situation, with different bimodules of coefficients and/or more general algebras.